Lippmann H G, Krüger W, Elsner G, Wolff H
Arch Geschwulstforsch. 1977;47(8):703-9.
The intratumoral activity of beta-Glucuronidase (total and free) was determined in surgical specimens of malignant tumors of the lung (N equal to 20) and of the breast (N equal to 15) from patients. A free beta-Glucuronidase-activity from about 90 mU per g tissue was found but there was no difference between both tumor types, and the beta-Glucuronidase-activity, as it seems, is not dependent on histological characteristics of the tumors. The findings are discussed under the view of the key function of the lysosomal enzymes in the concept of the "Cancer-Multistep-Therapy" by M. von Ardenne.
在取自患者的肺部恶性肿瘤（N = 20）和乳腺恶性肿瘤（N = 15）的手术标本中，测定了β-葡萄糖醛酸酶（总酶和游离酶）的瘤内活性。发现每克组织中游离β-葡萄糖醛酸酶活性约为90 mU，但两种肿瘤类型之间没有差异，而且β-葡萄糖醛酸酶活性似乎不依赖于肿瘤的组织学特征。从溶酶体酶在M.冯·阿登纳“癌症多步治疗”概念中的关键作用这一角度对这些发现进行了讨论。
