[The antihypertensive effect of a fixed combination of beta receptor blockaders and diuretics on the resting and exertion blood pressure of patients with essential hypertension].

Hypertensive patients are particularly endangered by disproportionately large increases in blood pressure during daily physical activity. It is of clinical importance to know how antihypertensive drugs influence these pressure changes and therefore the blood pressure lowering effect of the fixed combination of a beta-receptor antagonist and diuretics on exercise-induced blood pressure increases during and after standardized ergometric work was investigated in 32 outpatients with mild to moderate essential hypertension. This combination was shown to be an effective therapeutic regimen lowering blood pressure into the normotensive range at rest and particularly during and after ergometry. Side effects were minimal. In two-thirds of the patients a sufficient blood pressure reduction under all conditions could be achieved by a single morning dose of one tablet (10 mg timolol, 25 mg hydrochlorothiazide, and 2.5 mg amiloridehydrochloride).