Gaudy J H, Dauthier C, Férracci F, Boitier J F
Ann Anesthesiol Fr. 1980;21(2):145-7.
The effects of progressively increasing hyperoxia from 0.22 to 1 on the ventilatory action of a ventilatory analeptic with a peripheral action, almitrine, were studied in six dogs under deep anaesthesia by Alfatesine administered at a constant flow rate. At FiO2 = o.22, almitrine partially corrected hypoventilation. From FiO2 o.30 to FiO2 0.50, initial hypoventilation was unaltered. At FiO2 = 1, it was worsened. This preliminary study will need to be completed by examination of the interference almitrine-FiO2 at different levels of anaesthesia and of respiratory depression, by study of the effects of different levels of FiO2 on the respiratory depression caused by Alfatesine and by study of the effects of the sudden administration of pure oxygen.
在六只深度麻醉的狗身上，通过以恒定流速给予阿法他明，研究了从0.22逐渐增加到1的高氧对具有外周作用的呼吸兴奋药阿米三嗪的通气作用的影响。在FiO2 = 0.22时，阿米三嗪部分纠正了通气不足。从FiO2 0.30到FiO2 0.50，初始通气不足未改变。在FiO2 = 1时，通气不足恶化。这项初步研究需要通过检查不同麻醉水平和呼吸抑制情况下阿米三嗪-FiO2的干扰情况、研究不同FiO2水平对阿法他明引起的呼吸抑制的影响以及研究突然给予纯氧的影响来完成。
