Chardon P, Préfaut C, Kienlen J, Griffe O, du Cailar J
Ann Anesthesiol Fr. 1980;21(5):525-9.
Almitrine was injected intravenously at a dose of 1 mg.kg-1 over a period of sixty minutes in eight men aged from 49 to 69 years suffering from chronic bronchitis and obstructive airway disease, with signs of chronic cor pulmonale. During the study, patients on artificial respirator were in stable ventilation. Measurements gave the following results: arterial pO2 rose at all the times of study (P < 0.02). Arterial pCO2 decreased, the difference being significant 20 minutes after the end of the infusion. Q tended to increase accompanied by a slowing in heart rate, an increase in cardiac index and in systolic ejection work (P < 0.01 at T60). Pw increased (with P < 0.05 at the 20th minute) and subsequently varied in the same direction in parallel with pulmonary resistance. The authors concluded that almitrine, apart from its well known effects on ventilatory mechanics, results in blood gas changes with are not directly correlated with variations in VE by direct action on pulmonary vascular flow with any notable improvement in the upper zones of the lung.
对8名年龄在49至69岁之间、患有慢性支气管炎和阻塞性气道疾病且有慢性肺源性心脏病体征的男性患者，在60分钟内静脉注射1毫克/千克的烯丙哌三嗪。研究期间，使用人工呼吸器的患者通气稳定。测量结果如下：在研究的所有时间点，动脉血氧分压均升高（P<0.02）。动脉血二氧化碳分压降低，输液结束20分钟后差异显著。心输出量有增加趋势，同时心率减慢、心脏指数和心脏收缩射血功增加（在60分钟时P<0.01）。肺动脉楔压升高（在第20分钟时P<0.05），随后与肺阻力呈相同方向平行变化。作者得出结论，烯丙哌三嗪除了对通气力学有众所周知的作用外，还会导致血气变化，这种变化与通过对肺血管血流的直接作用引起的每分钟通气量变化没有直接关联，且肺部上叶有明显改善。
