生长抑素抑制甲状旁腺激素分泌的作用机制。

Mode of action of somatostatin in inhibiting parathyroid hormone secretion.

作者信息

Kukreja S C, Hargis G K, Bowser E N, Williams G A

出版信息

Horm Metab Res. 1980 Nov;12(11):621-4. doi: 10.1055/s-2007-999214.

DOI:10.1055/s-2007-999214

Abstract

Effects of somatostatin on basal and low calcium-, isoproterenol- or dibutryl cyclic AMP (DBcAMP)-stimulated parathyroid hormone (PTH) secretion were evaluated in vitro with bovine parathyroid tissue. Low calcium, isoproterenol or DBcAMP alone significantly stimulated PTH secretion. Somatostatin 1 or 4 microgram/ml significantly inhibited these stimulated PTH secretions. Inhibition of isoproterenol-stimulated PTH secretion was more complete than was the inhibition of low calcium- or DBcAMP-stimulated secretion. The studies indicate that somatostatin inhibits PTH secretion by an action distal to cAMP generation. The more complete inhibition of isoproterenol-stimulated PTH secretion suggests that somatostatin may also have additional effects on or proximal to the formation of cyclic AMP.

摘要

利用牛甲状旁腺组织在体外评估了生长抑素对基础状态以及低钙、异丙肾上腺素或二丁酰环磷腺苷（DBcAMP）刺激的甲状旁腺激素（PTH）分泌的影响。单独的低钙、异丙肾上腺素或DBcAMP显著刺激PTH分泌。1或4微克/毫升的生长抑素显著抑制这些刺激的PTH分泌。对异丙肾上腺素刺激的PTH分泌的抑制比对低钙或DBcAMP刺激的分泌的抑制更完全。这些研究表明，生长抑素通过在环磷腺苷生成远端的作用抑制PTH分泌。对异丙肾上腺素刺激的PTH分泌的更完全抑制表明，生长抑素可能对环磷腺苷的形成也有额外的作用或在其近端起作用。