Scherer H, Bschorr J
Laryngol Rhinol Otol (Stuttg). 1980 Aug;59(8):477-84.
The testing by different methods of the effectiveness of three anti-vertiginous drugs (Diphenhydramine, L-Hyoscyamine, and PB 795) has also yielded interesting results concerning the benefit-cost ratio of the methods employed. Sustained thermal stimulation enables better observation of the kind of effect produced by a drug on the nystagmus, the onset and development of this effect, than repeated rotatory stimuli. From among methods employed in testing motion-sickness symptoms the measuring of perspiration on a definite area of the forehead has proved simplest and most reliable. Habituation is negligible, whereas it is marked during analysis of subjective symptoms and when psycho-galvanic skin reflexes are measured. Diphenhydramin proved more effective than the other drugs tested. Its rapid effect in the form of intravenous injection makes it very suitable for emergency situations such as the treatment of Menière's attack. L-Hyoscyamin is suitable when sedation is undesirable. PB 795, a anti-depressant is effective but produces disturbance of accommodation as a side effect, so that it appears unsuitable for treating motion-sickness.
通过不同方法对三种抗眩晕药物（苯海拉明、氢溴酸东莨菪碱和PB 795）的有效性进行测试，也得出了有关所用方法的效益成本比的有趣结果。与重复旋转刺激相比，持续热刺激能够更好地观察药物对眼球震颤产生的效果类型、这种效果的起始和发展情况。在测试晕动病症状的方法中，测量前额特定区域的出汗情况已被证明是最简单且最可靠的。习惯化可忽略不计，而在分析主观症状以及测量心理皮肤电反射时则很明显。事实证明，苯海拉明比其他受试药物更有效。其静脉注射形式的快速起效使其非常适合诸如治疗梅尼埃病发作等紧急情况。当不需要镇静作用时，氢溴酸东莨菪碱是适用的。PB 795是一种抗抑郁药，有效但会产生调节障碍作为副作用，因此似乎不适合治疗晕动病。
