致死性照射与造血细胞移植之间时间间隔长度的意义。
Significance of the length of time interval between lethal irradiation and transplantation of haemopoietic cells.
作者信息
Petýrek P
出版信息
Folia Biol (Praha). 1981;27(1):41-50.
PMID:6110568
Abstract
It could be shown that the efficiency of haemopoietic cell transplantation into lethally irradiated mice depended upon the degree of histocompatibility between the donor and the host as well as on the number of transplanted cells. With a prolongation of the time interval between irradiation and transplantation a proportionally higher number of transplanted haemopoietic cells was required to maintain the curative effect of transplantation. The haemopoietic microenvironment in lethally exposed mice remained unchanged until the tenth day after irradiation.
摘要
可以证明，将造血细胞移植到经致死剂量照射的小鼠体内的效率，取决于供体与宿主之间的组织相容性程度以及移植细胞的数量。随着照射与移植之间时间间隔的延长，为维持移植的治疗效果，所需移植的造血细胞数量成比例增加。在接受致死剂量照射的小鼠中，造血微环境在照射后第十天之前保持不变。
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