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阻塞性气道疾病药物治疗的最新进展,特别关注支气管哮喘(作者译)

[Recent aspects of pharmacotherapy in obstructive airway diseases with special regard to bronchial asthma (author's transl)].

作者信息

Triebe G, Julich H

出版信息

Z Erkr Atmungsorgane. 1980;155(1):3-20.

PMID:6111162
Abstract

After demonstration of the pathophysiologic principles bronchial obstruction a review of the pharmacotherapeutic possibilities is presented. The main of therapeutics comprehends beta-2-receptor stimulants in combination with theophylline derivatives. Further therapeutic efforts with anticholinergic drugs (ipratropium bromide) preponderant in chronic bronchitis or intrinsic bronchial asthma respectively and with cromolyn sodium in extrinsic asthma are valuable. Glucocorticoids are allowed to be given only after exhaustion of all other modes of treatment, if possible as intermittent long term treatment. The stimulation of expectoration is an essential part of pharmacotherapy. The complex application of less specific methods of pharmacotherapy and physiotherapy belongs to the comprehensive treatment of patients. The threatening life asthmatic status demands the appropriate use of all possibilities of pharmacotherapy and intensive care if necessary.

摘要

在阐述了支气管阻塞的病理生理原理后,本文介绍了药物治疗的可能性。主要治疗方法包括β-2受体激动剂与茶碱衍生物联合使用。抗胆碱能药物(异丙托溴铵)分别在慢性支气管炎或内源性支气管哮喘中占主导地位,色甘酸钠在外源性哮喘中的进一步治疗作用也很重要。糖皮质激素只有在所有其他治疗方法都无效后才允许使用,如有可能应采用间歇性长期治疗。促进排痰是药物治疗的重要组成部分。药物治疗和物理治疗等不太特异的方法的综合应用属于患者的综合治疗。危及生命的哮喘状态需要必要时适当利用所有药物治疗和重症监护的可能性。

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