Kaplay S S, Prema K
Clin Chim Acta. 1981 Feb 19;110(1):27-33. doi: 10.1016/0009-8981(81)90296-5.
Plasma and erythrocyte Na+ and K+ and erythrocyte membrane (EM) Na+, K+ ATPase, Mg2+ ATPase and Ca2+, Mg2+ Atpase activities were studied in four groups of women -- non-pregnant, normal pregnant, with pregnancy edema (PE) and with pregnancy induced hypertension (PIH). The effect of diuretic therapy in PE and PIH was also evaluated. Plasma Na+ concentration was higher in PE and PIH. There was a significant reduction in (Na+ + K+) ratio between cell and plasma in these two groups. EM Na+, K+ ATPase was unaltered in PE and PIH. The Mg2+ ATPase was elevated by 44% in PE and by 100% in PIH subjects. There was a 50% reduction in Ca2+, Mg2+ ATPase activity in PE. Diuretic therapy had no effect either on electrolyte levels or on any of the EM ATPases. From these results it may be concluded that Na, K, ATPase -- which in kidney is a site of action for furosemide, a potent diuretic -- is unaffected in PE and PIH and, hence, treatment with diuretics -- is unaffected in PE and PIH and, hence, treatment with diuretics in such patients may be ineffective.
对四组女性进行了研究，包括未怀孕女性、正常怀孕女性、患有妊娠水肿（PE）的女性和患有妊娠高血压（PIH）的女性，检测了她们血浆和红细胞中的钠（Na+）、钾（K+）以及红细胞膜（EM）上的钠钾ATP酶、镁ATP酶和钙镁ATP酶的活性。同时还评估了利尿剂治疗对PE和PIH的效果。PE和PIH患者的血浆钠浓度较高。这两组患者细胞与血浆之间的（Na+ + K+）比值显著降低。PE和PIH患者的EM钠钾ATP酶未发生变化。PE患者的镁ATP酶升高了44%，PIH患者升高了100%。PE患者的钙镁ATP酶活性降低了50%。利尿剂治疗对电解质水平或任何一种EM ATP酶均无影响。从这些结果可以得出结论，钠钾ATP酶（在肾脏中是强效利尿剂呋塞米的作用位点）在PE和PIH中未受影响，因此，在这类患者中使用利尿剂治疗可能无效。
