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哌甲酯样兴奋剂在体外释放[3H]酪胺，但不释放[14C]多巴胺。

Methylphenidate-like stimulants in vitro release [3H]tyramines but not [14C]dopamine.

作者信息

Dyck L E

出版信息

Eur J Pharmacol. 1981 Jan 29;69(3):371-4. doi: 10.1016/0014-2999(81)90486-6.

DOI:10.1016/0014-2999(81)90486-6
PMID:6111462
Abstract

The effects of methylphenidate, cocaine, nomifensine and amfonelic acid on the simultaneous uptake and release of [14C]dopamine and [3H]p-tyramine or [3H]m-tyramine were examined in rat striatal slices. While the uptake of each amine was inhibited equally by each drug, only [3H]tyramines were released. The d-amphetamine-induced release of [14C]dopamine and [3H]p-tyramine was antagonized by these drugs. These findings suggest that the tyramines can be transported independently from dopamine.

摘要

在大鼠纹状体切片中研究了哌醋甲酯、可卡因、诺米芬辛和安非他明酸对[14C]多巴胺与[3H]对酪胺或[3H]间酪胺同时摄取和释放的影响。虽然每种药物对每种胺的摄取抑制程度相同，但只有[3H]酪胺被释放。这些药物拮抗了右旋苯丙胺诱导的[14C]多巴胺和[3H]对酪胺的释放。这些发现表明酪胺可以独立于多巴胺进行转运。

相似文献

1
Methylphenidate-like stimulants in vitro release [3H]tyramines but not [14C]dopamine.哌甲酯样兴奋剂在体外释放[3H]酪胺，但不释放[14C]多巴胺。
Eur J Pharmacol. 1981 Jan 29;69(3):371-4. doi: 10.1016/0014-2999(81)90486-6.
2
A comparison of the effects of methylphenidate and amphetamine on the simultaneous release of radiolabelled dopamine and p- or m-tyramine from rat striatal slices.哌醋甲酯和苯丙胺对大鼠纹状体切片中放射性标记多巴胺与对-或间-酪胺同时释放影响的比较。
Eur J Pharmacol. 1980 Nov 7;68(1):33-40. doi: 10.1016/0014-2999(80)90057-6.
3
Differences between electrically-, ritalin- and D-amphetamine-stimulated release of [3H]dopamine from brain slices suggest impaired vesicular storage of dopamine in an animal model of Attention-Deficit Hyperactivity Disorder.电刺激、利他林和右旋苯丙胺刺激从脑切片中释放[3H]多巴胺之间的差异表明，在注意力缺陷多动障碍动物模型中多巴胺的囊泡储存受损。
Behav Brain Res. 1998 Jul;94(1):163-71. doi: 10.1016/s0166-4328(97)00177-0.
4
Similar dopamine-releasing effects of phencyclidine and nonamphetamine stimulants in striatal slices.苯环利定和非苯丙胺类兴奋剂在纹状体切片中类似的多巴胺释放效应。
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5
Release of radiolabeled dopamine, p-tyramine, and m-tyramine from rat striatal slices by some aminotetralins.某些氨基四氢萘从大鼠纹状体切片中释放放射性标记的多巴胺、对酪胺和间酪胺。
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Effects of amphetamine and amfonelic acid on the disposition of striatal newly synthesized dopamine.苯丙胺和安福酚酸对纹状体新合成多巴胺处置的影响。
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8
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Methylphenidate-like effects of the new antidepressant drug nomifensine (HOE 984).新型抗抑郁药诺米芬辛（HOE 984）的哌甲酯样效应
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10
The effects of amfonelic acid and some other central stimulants on mouse striatal tyramine, dopamine and homovanillic acid.安福酚酸及其他一些中枢兴奋剂对小鼠纹状体酪胺、多巴胺和高香草酸的影响。
Br J Pharmacol. 1982 Nov;77(3):511-5. doi: 10.1111/j.1476-5381.1982.tb09325.x.

引用本文的文献

1
Release of radiolabeled dopamine, p-tyramine, and m-tyramine from rat striatal slices by some aminotetralins.某些氨基四氢萘从大鼠纹状体切片中释放放射性标记的多巴胺、对酪胺和间酪胺。
Neurochem Res. 1981 Apr;6(4):365-75. doi: 10.1007/BF00963851.
2
The effects of amfonelic acid and some other central stimulants on mouse striatal tyramine, dopamine and homovanillic acid.安福酚酸及其他一些中枢兴奋剂对小鼠纹状体酪胺、多巴胺和高香草酸的影响。
Br J Pharmacol. 1982 Nov;77(3):511-5. doi: 10.1111/j.1476-5381.1982.tb09325.x.