通过用纯化的K99或987P菌毛对母猪进行免疫接种，使哺乳仔猪对产肠毒素大肠杆菌引起的腹泻病产生免疫：接种疫苗后的抗体产生情况
Immunization of suckling pigs against enterotoxigenic Escherichia coli-induced diarrheal disease by vaccinating dams with purified K99 or 987P pili: antibody production in response to vaccination.
作者信息
Isaacson R E, Dean E A, Morgan R L, Moon H W
出版信息
Infect Immun. 1980 Aug;29(2):824-6. doi: 10.1128/iai.29.2.824-826.1980.
Abstract
Pilus-specific antibody levels measured by enzyme-linked immunosorbent assays in serum and colostrum of pregnant swine (dams) were shown to increase after parenteral vaccination with pili. Pilus-specific antibody levels in dams were correlated with protection of their suckling offspring against fatal diarrhea caused by enterotoxigenic Escherichia coli possessing the same pilus as the vaccine.
摘要
通过酶联免疫吸附测定法检测发现，妊娠母猪（母体）血清和初乳中的菌毛特异性抗体水平在经菌毛进行肠胃外疫苗接种后有所升高。母体中的菌毛特异性抗体水平与保护其哺乳后代免受由具有与疫苗相同菌毛的产肠毒素大肠杆菌引起的致命腹泻相关。
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