Pederson R A, McIntosh C H, Mueller M K, Brown J C
Regul Pept. 1981 Apr;2(1):53-60. doi: 10.1016/0167-0115(81)90065-3.
The possible interaction between somatostatin-like immunoreactivity (SLI) and immunoreactive-gastrin release was studied in an isolated perfused rat stomach preparation. Gastrin release was abolished by antrectomy but basal and gastric inhibitory polypeptide-stimulated SLI levels were unchanged from control experiments, implicating the corpus as the major source of SLI released into the vasculature. Perfused stomachs of vagotomized rats exhibited basal hypergastrinaemia with no alteration in basal or stimulated SLI release, suggesting an uncoupling of SLI and gastrin release. This study indicated that SLI released into the vasculature originated in the acid secretory region of the stomach and therefore may be involved in the regulation of acid secretion at the level of the parietal cell mass.
在离体灌注大鼠胃标本中研究了生长抑素样免疫反应性（SLI）与免疫反应性胃泌素释放之间可能的相互作用。胃窦切除术后胃泌素释放被消除，但基础和胃抑制多肽刺激的SLI水平与对照实验相比没有变化，这表明胃体是释放到血管系统中的SLI的主要来源。迷走神经切断术大鼠的灌注胃表现出基础高胃泌素血症，基础或刺激的SLI释放没有改变，提示SLI和胃泌素释放解偶联。本研究表明，释放到血管系统中的SLI起源于胃的泌酸区域，因此可能在壁细胞群水平参与胃酸分泌的调节。
