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应激大鼠学习能力与记忆的老年学初步研究(作者译)

[Gerontological pilot study on learning ability and memory in the stressed rat (author's transl)].

作者信息

Bubna-Littitz H, Hofecker G, Kment A, Niedermüller H

出版信息

Aktuelle Gerontol. 1981 Jan;11(1):28-31.

PMID:6112892
Abstract

The influence of noise and overcrowding on the learning ability and memory was investigated during a long term cohort study in 120 male Sprague Dawley rats covering an age range from 8 to 14 months. The investigations were performed by means of a semi-automatical multiple-T-maze with 7 choice points. The results showed that noise and overcrowding enhanced the learning ability and memory in rats up to an age of 10 to 12 months. However, the learning ability and memory were declining faster with age in the stressed animals than in the unstressed ones. The stressor "overcrowding" proved to be more effective than the stressor "noise" applied by the authors.

摘要

在一项针对120只8至14个月大的雄性斯普拉格-道利大鼠的长期队列研究中,研究了噪音和拥挤对学习能力及记忆的影响。研究通过一个具有7个选择点的半自动多T迷宫进行。结果显示,在10至12个月龄之前,噪音和拥挤增强了大鼠的学习能力及记忆。然而,与未受应激的动物相比,应激动物的学习能力和记忆随年龄增长下降得更快。事实证明,应激源“拥挤”比作者所应用的应激源“噪音”更具影响力。

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