The proliferative activity of the adrenal cortex as influenced by carcinogenic and noncarcinogenic substances. - Suppr | 超能文献

The proliferative activity of the adrenal cortex as influenced by carcinogenic and noncarcinogenic substances.

作者信息

Danz M, Urban H, Stiller K J, Amlacher E

出版信息

Exp Pathol (Jena). 1975;11(3-4):142-7. doi: 10.1016/s0014-4908(75)80054-8.

DOI:10.1016/s0014-4908(75)80054-8

PMID:61132

Abstract

A single oral toxic dose of carcinogens (N-nitrosomorpholine, aflatoxin B1, N--methyl-N-nitrosourea, urethan) causes a significant increase of the mitotic rate in the adrenal cortex 48 hours after application. Both, the control animals (water via stomach tube) and the animals treated with acetylsalicylic acid, arsenic, phenol and actinomycin D do not produce this effect. These findings confirm our previous results obtained by administration of acetylaminofluorene, diethylnitrosamine, dimethylnitrosamine and trinitroso-trimethylen-triamine. It is possible that the increased mitotic activity of the adrenal cortex is correlated with the substances applied.

摘要

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