单次中毒剂量的2-乙酰氨基芴或烯丙醇对肾上腺的作用。I. 肾上腺重量及肾上腺皮质细胞有丝分裂活性的变化

The action of a single toxic dose of 2-acetylaminofluorene or allylic alcohol on the adrenals. I. Behaviour of organ weight and mitotic activity of the adrenocortical cells.

作者信息

Danz M, Urban H, Jäger A, Trautvetter P

出版信息

Exp Pathol (Jena). 1976;12(6):301-8. doi: 10.1016/s0014-4908(76)80004-x.

Abstract

In male Sprague-Dawley rats the relative organ weight and mitotic activity of the adrenal cortex were investigated after intoxication by a single dose of 200 mg/kg b.w. of 2-acetylaminofluorene (AAF) or 20 mg/kg b.w. of allylic alcohol (ALL). 36, 42, 48 and 72 hours after application a significant enhancement of the mitotic rate of the adrenocortical cells was produced by AAF in comparison with that following ALL administration. Interrelations of organ weight and proliferative activity could not be found.

摘要

在雄性斯普拉格-道利大鼠中，单次给予体重200mg/kg的2-乙酰氨基芴（AAF）或体重20mg/kg的烯丙醇（ALL）使其中毒后，对肾上腺皮质的相对器官重量和有丝分裂活性进行了研究。给药后36、42、48和72小时，与给予ALL后相比，AAF使肾上腺皮质细胞的有丝分裂率显著提高。未发现器官重量与增殖活性之间的相互关系。