Swift T R
Muscle Nerve. 1981 Jul-Aug;4(4):334-53. doi: 10.1002/mus.880040410.
Disorders of neuromuscular transmission in humans are caused by a wide variety of agents including systemic diseases, drugs, environmental toxins, animal envenomation, cations, and hormones. Some are genetically determined. Many are of known etiology. All such disorders interfere with one or more events in the sequence whereby a nerve impulse excites a muscle action potential. In many disorders of neuromuscular transmission, abnormal fatigue occurs, and some cases respond dramatically to treatment. Investigation of the microphysiology, microanatomy, and pharmacology of both normal and diseased neuromuscular junctions has increased our knowledge of these disorders.
人类神经肌肉传递障碍由多种因素引起，包括全身性疾病、药物、环境毒素、动物毒液、阳离子和激素。有些是由遗传决定的。许多病因已知。所有这些障碍都会干扰神经冲动激发肌肉动作电位这一过程中的一个或多个环节。在许多神经肌肉传递障碍中，会出现异常疲劳，有些病例对治疗反应显著。对正常和患病神经肌肉接头的微观生理学、微观解剖学和药理学研究，增加了我们对这些障碍的了解。
