β受体阻滞剂撤药后的肾上腺素能超敏反应。
Adrenergic hypersensitivity after beta-blocker withdrawal.
作者信息
Ross P J, Lewis M J, Sheridan D J, Henderson A H
出版信息
Br Heart J. 1981 Jun;45(6):637-42. doi: 10.1136/hrt.45.6.637.
Abstract
We investigated the possibility of a rebound increase in sympathetic response after stopping beta-blocker treatment by measuring heart rate under conditions of increased sympathetic drive, as provided by standing with vasodilatation, or the Valsalva manoeuvure. Significant rebound increases in heart rate were observed after stopping propranolol given for one or more weeks but not when given for only four days. The amplitude of the rebound heart rate relative to the control heart rate off beta-blockers was similar after propranolol, atenolol, oxprenolol, or acebutolol, and in hyperthyroid subjects.
摘要
我们通过在交感神经驱动增加的条件下测量心率，研究了停用β受体阻滞剂治疗后交感神经反应出现反跳性增加的可能性，交感神经驱动增加的条件包括站立伴血管舒张或瓦尔萨尔瓦动作。在停用服用一周或更长时间的普萘洛尔后，观察到心率有显著的反跳性增加，但仅服用四天时则未观察到。普萘洛尔、阿替洛尔、氧烯洛尔或醋丁洛尔停药后，以及在甲状腺功能亢进患者中，相对于停用β受体阻滞剂后的对照心率，反跳性心率的幅度相似。
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