停用氧烯洛尔后的β-肾上腺素能受体超敏反应：不一致的结果并非方法学所致。
beta-Adrenoceptor hypersensitivity after stopping oxprenolol: discrepant findings not attributable to methodology.
作者信息
Singh H, Rimmer A, Lewis M J, Henderson A H
出版信息
Br J Clin Pharmacol. 1983 Dec;16(6):722-4. doi: 10.1111/j.1365-2125.1983.tb02249.x.
Using isoprenaline and glyceryl trinitrate (GTN) induced tachycardia we have compared the rebound beta-adrenoceptor hypersensitivity on stopping slow-release and conventional oxprenolol in young normotensive subjects. Heart rate on standing with GTN rose after stopping slow-release and conventional oxprenolol to peak levels on day 2 or 3 significantly greater than corresponding control levels off treatment on day 5. The isoprenaline CD25 (the dose required to increase heart rate by 25 beats/min) fell after stopping conventional oxprenolol to a significantly lower level on day 3 than the control level off treatment on day 5. Contrary to a recent report describing no rebound beta-adrenoceptor hypersensitivity on stopping slow-release oxprenolol we have demonstrated it after stopping slow release as well as conventional oxprenolol.
我们使用异丙肾上腺素和硝酸甘油（GTN）诱发心动过速，比较了年轻血压正常受试者停用缓释型和常规氧烯洛尔后β-肾上腺素能受体的反弹性超敏反应。停用缓释型和常规氧烯洛尔后，站立时使用GTN的心率在第2天或第3天升至峰值水平，显著高于第5天相应的停药对照水平。停用常规氧烯洛尔后，异丙肾上腺素CD25（使心率增加25次/分钟所需的剂量）在第3天降至显著低于第5天停药对照水平。与最近一篇报道称停用缓释型氧烯洛尔后无β-肾上腺素能受体反弹性超敏反应相反，我们证实了停用缓释型和常规氧烯洛尔后均会出现这种情况。
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