Schulte-Wissermann H, Gardilcic S
Monatsschr Kinderheilkd. 1981 Jul;129(7):378-90.
The central role of the thymus in the development of immunocompetence is demonstrated in a comprehensive survey. The origin and maturation of the thymocytes, clonal expansion, and the induction of tolerance are discussed in detail. It appears that the major-histocompatibility-antigens play an important role in the maturation processes of the thymocytes. They are probably made available to the developing cells by thymic macrophages. Dysfunction of the thymus leads to immunodeficiencies as well as autoimmune diseases. The heterogeneity of these diseases as well as various therapeutic possibilities for achieving immunologic reconstitution are discussed.
一项全面的调查证实了胸腺在免疫能力发育中的核心作用。详细讨论了胸腺细胞的起源与成熟、克隆扩增以及耐受性的诱导。主要组织相容性抗原似乎在胸腺细胞的成熟过程中发挥重要作用。它们可能由胸腺巨噬细胞提供给发育中的细胞。胸腺功能障碍会导致免疫缺陷以及自身免疫性疾病。文中讨论了这些疾病的异质性以及实现免疫重建的各种治疗可能性。
