Filipponi P, Nicoletti I, Santori P, Marcelli M, Gregorini G, Santeusanio F, Fussgaenger R D
Boll Soc Ital Biol Sper. 1981 Apr 30;57(8):864-70.
Two groups of receptors, one which develops a stimulating effect (alpha 1), the other an inhibitory effect hae recently been isolated in the alpha adrenergic group. In order to type the B cell adrenergic receptor of the endocrine pancreas, which mediates the inhibitory action exerted by the catecholamines on insulin secretion, the release of this hormone was evaluated in the presence of five alpha simpathomimetic substances that have a decreasing degree of efficiency on the adrenergic alpha 2 receptor of the presynaptic sympathic nerve terminal. The order of potency with which the alpha agonists tested depressed IRI secretion is superimposable on that of their potency on the sympathetic nerve and alpha 2 receptor. We concluded that adrenergic inhibition of insulin secretion is mediated by an alpha 2 receptor.
最近在α肾上腺素能组中分离出两组受体，一组产生刺激作用（α1），另一组产生抑制作用。为了确定内分泌胰腺的B细胞肾上腺素能受体类型，该受体介导儿茶酚胺对胰岛素分泌的抑制作用，在五种对突触前交感神经末梢的肾上腺素能α2受体作用效率递减的α拟交感神经物质存在的情况下，评估了这种激素的释放。所测试的α激动剂抑制IRI分泌的效力顺序与它们对交感神经和α2受体的效力顺序一致。我们得出结论，肾上腺素能对胰岛素分泌的抑制作用是由α2受体介导的。
