腺苷酸环化酶缺陷的大肠杆菌突变体中的鸟苷酸环化酶活性。
Guanylate cyclase activity in Escherichia coli mutants defective in adenylate cyclase.
作者信息
Macchia V, Caputo G, Mandato E, Rocino A, Adhya S, Pastan I
出版信息
J Bacteriol. 1981 Sep;147(3):931-4. doi: 10.1128/jb.147.3.931-934.1981.
Abstract
Guanylate cyclase, which catalyzes the synthesis of guanosine 3',5'-monophosphate, has been assayed in several strains of Escherichia coli. They include wild-type cells and mutants defective in adenylate cyclase, which is responsible for the synthesis of adenosine 3',5'-phosphate. Our results demonstrate that adenylate cyclase and guanylate cyclase are two different enzymes in E. coli and suggest that the gene that encodes adenylate cyclase also plays a regulatory role in the synthesis of guanylate cyclase.
摘要
催化3',5'-环磷酸鸟苷合成的鸟苷酸环化酶已在几种大肠杆菌菌株中进行了测定。这些菌株包括野生型细胞和腺苷酸环化酶缺陷型突变体，腺苷酸环化酶负责3',5'-环磷酸腺苷的合成。我们的结果表明，腺苷酸环化酶和鸟苷酸环化酶在大肠杆菌中是两种不同的酶，并表明编码腺苷酸环化酶的基因在鸟苷酸环化酶的合成中也起调节作用。
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