大肠杆菌在短暂抑制和分解代谢物阻遏期间的环3':5'-腺苷单磷酸
Cyclic 3':5'-adenosine monophosphate in Escherichia coli during transient and catabolite repression.
作者信息
Wayne P K, Rosen O M
出版信息
Proc Natl Acad Sci U S A. 1974 Apr;71(4):1436-40. doi: 10.1073/pnas.71.4.1436.
Abstract
Cyclic AMP concentrations were low for an adenylate cyclase-deficient mutant (cya(-)) and abnormally high for a catabolite receptor protein-deficient mutant (crp(-)). A fall in cellular cAMP concentration was always found when cells were subjected to transient repression. No consistent correlations were observed between catabolite repression and cellular cAMP levels.
摘要
对于腺苷酸环化酶缺陷型突变体（cya(-)），环磷酸腺苷（cAMP）浓度较低；而对于分解代谢物受体蛋白缺陷型突变体（crp(-)），cAMP浓度则异常高。当细胞受到短暂阻遏时，总是会发现细胞内cAMP浓度下降。在分解代谢物阻遏与细胞内cAMP水平之间未观察到一致的相关性。
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