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Characteristics of androgen binding in rat adrenal tissue using [3H]methyltrienolone (R1881) as tracer.

作者信息

Asselin J, Melancon R

出版信息

Steroids. 1977 Nov;30(5):591-604. doi: 10.1016/0039-128x(77)90050-2.

DOI:10.1016/0039-128x(77)90050-2
PMID:611628
Abstract

A high level of binding of [3H]methyltrienolone (R1881 = 17beta-hydroxy-17alpha-methyl-estra-4, 9, 11-trien-3-one) was found in cytosol prepared from adrenals of castrated male rats. Binding of [3H]R1881 was of high affinity (DK = 6.2 nM) and highly specific for androgens. The [3H]R1881 complex migrates at 7-9S on sucrose gradients in low ionic strength buffer and at 4-5S in buffer containing 0.4M KC1. All binding studies have been performed in parallel with rat ventral prostate and adrenal cytosol. The present data suggest the presence of an androgen binding component in rat adrenal tissue.

摘要

相似文献

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