Houston M C
South Med J. 1981 Sep;74(9):1112-23. doi: 10.1097/00007611-198109000-00026.
The abrupt cessation of antihypertensive medication is usually without immediate consequence but may be associated with symptoms and signs of enhanced sympathetic activity, severe hypertension, morbid ischemic cardiovascular events, or death. This syndrome is more common after discontinuation of high doses of centrally acting antiadrenergic and beta-adrenergic blocking drugs or combination antihypertensive therapy, but it also occurs with numerous antihypertensive agents. Predisposing factors include ischemic heart disease, severe hypertension, renovascular or high renin hypertension, and high doses of multiple antihypertensive drugs. Gradual tapering of antihypertensive medications over seven to ten days will prevent symptoms and marked elevation of blood pressure. Should a discontinuation syndrome develop, re-administration of the drug previously discontinued is the most appropriate treatment.
突然停用抗高血压药物通常不会立即产生后果，但可能会出现交感神经活动增强、严重高血压、缺血性心血管疾病或死亡等症状和体征。这种综合征在停用高剂量的中枢作用抗肾上腺素能和β-肾上腺素能阻断药物或联合抗高血压治疗后更为常见，但也可发生于多种抗高血压药物。易感因素包括缺血性心脏病、严重高血压、肾血管性高血压或高肾素性高血压以及高剂量的多种抗高血压药物。在7至10天内逐渐减少抗高血压药物的用量可预防症状和血压的显著升高。如果出现停药综合征，重新使用先前停用的药物是最合适的治疗方法。
