Bligh J
Fed Proc. 1981 Nov;40(13):2746-9.
Of the amino acids that affect the activity of central neurons, aspartate and glutamate (which exert generally excitatory influences) and glycine, taurine, and gamma-aminobutyric acid (GABA) (which generally exert inhibitory influences) are the strongest neurotransmitter candidates. As with other putative transmitter substances, their effects on body temperature when injected into the cerebral ventricles or the preoptic hypothalamus tend to vary within and between species. These effects are uninterpretable without accompanying information regarding effector activity changes and the influences of dose and ambient temperature. Observations necessary for analysis of apparent action have been made in studies of the effects of intracerebroventricular injections of these amino acids into sheep. Aspartate and glutamate have similar excitatory effects on the neural pathways that activate both heat production and heat loss effectors. Glycine appears to be without effect.
在影响中枢神经元活性的氨基酸中，天冬氨酸和谷氨酸（通常发挥兴奋性影响）以及甘氨酸、牛磺酸和γ-氨基丁酸（GABA）（通常发挥抑制性影响）是最强的神经递质候选物。与其他假定的递质物质一样，当将它们注入脑室或视前区下丘脑时，其对体温的影响在种内和种间往往有所不同。如果没有关于效应器活动变化以及剂量和环境温度影响的伴随信息，这些影响就无法解释。在对绵羊进行脑室内注射这些氨基酸的效应研究中，已经进行了分析明显作用所需的观察。天冬氨酸和谷氨酸对激活产热和散热效应器的神经通路具有相似的兴奋作用。甘氨酸似乎没有作用。
