L-谷氨酸对离体大鼠视网膜释放[14C]γ-氨基丁酸的影响。

Effect of L-glutamic acid on [14C]GABA release from isolated rat retina.

作者信息

Kamada Y, Mizuno A, Matsuda M

出版信息

Brain Res. 1981 Dec 14;229(1):251-5. doi: 10.1016/0006-8993(81)90766-6.

Abstract

The effect of various putative neurotransmitters on the release of [14C]GABA taken up by isolated rat retina was investigated by a perfusion technique. L-Glutamic acid initially enhanced the GABA release and subsequently reduced it to a level below the baseline rate. This enhancing effect of L-glutamic acid was Ca2+-dependent and tetrodotoxin-sensitive. L-Aspartic acid only reduced the GABA release, whereas kainic acid exhibited only a marked enhancement of its release. Acetylcholine, norepinephrine, dopamine, glycine and taurine did not have any significant effects on GABA release.

摘要

采用灌注技术研究了各种假定神经递质对分离的大鼠视网膜摄取的[14C]γ-氨基丁酸（GABA）释放的影响。L-谷氨酸最初增强了GABA的释放，随后将其降低至基线速率以下的水平。L-谷氨酸的这种增强作用依赖于钙离子且对河豚毒素敏感。L-天冬氨酸仅降低了GABA的释放，而红藻氨酸仅显著增强了其释放。乙酰胆碱、去甲肾上腺素、多巴胺、甘氨酸和牛磺酸对GABA的释放没有任何显著影响。