垂体切除及生长激素给药对大鼠胃中生长抑素和胃泌素含量的影响。

Effect of hypophysectomy and growth hormone administration on somatostatin and gastrin content in the stomach of rats.

作者信息

Kasanuki J, Makino H, Matsushima Y, Kanatsuka A, Miyahira M, Tokumasa Y, Kumagai A

出版信息

Endocrinol Jpn. 1981 Jun;28(3):257-60. doi: 10.1507/endocrj1954.28.257.

DOI:10.1507/endocrj1954.28.257

Abstract

The effect of hypophysectomy and bovine growth hormone (GH) administration on somatostatin (SRIF) content as well as gastrin content in the rat stomach was investigated. SRIF content was determined by a specific radioimmunoassay. The total SRIF content in the stomach had decreased 4 weeks after hypophysectomy but was restored significantly in those rats which were subjected to bovine GH administration for 7 days after hypophysectomy. Furthermore, in control rats, an increase in SRIF content in the stomach was observed after 7 days of GH administration. Similar changes in total content of gastrin were observed after hypophysectomy and bovine GH administration, although these changes were not significant. These results indicate that GH may influence gastric function through changes in SRIF and gastrin content in the stomach.

摘要

研究了垂体切除和注射牛生长激素（GH）对大鼠胃中生长抑素（SRIF）含量以及胃泌素含量的影响。采用特异性放射免疫分析法测定SRIF含量。垂体切除4周后胃中总SRIF含量降低，但在垂体切除后接受7天牛GH注射的大鼠中显著恢复。此外，在对照大鼠中，注射GH 7天后观察到胃中SRIF含量增加。垂体切除和注射牛GH后，胃泌素总含量也有类似变化，尽管这些变化不显著。这些结果表明，GH可能通过改变胃中SRIF和胃泌素的含量来影响胃功能。