Kanatsuka A, Makino H, Matsushima Y, Osegawa M, Yamamoto M, Kumagai A
Neuroendocrinology. 1979;29(3):186-90. doi: 10.1159/000122921.
The effect of hypophysectomy and bovine GH administration on somatostatin (SRIF) content in the rat hypothalamus was investigated. SRIF content was determined by a specific radioimmunoassay method described elsewhere. The total SRIF content of the rat hypothalamus as well as its content per milligram wet weight had decreased 4 weeks after hypophysectomy but was restored significantly in those rats which were subjected to bovine GH administration for 7 days 3 weeks after hypophysectomy. Furthermore, in nonoperated rats, increase of hypothalamic SRIF content was observed after 7 days GH administration. These results indicate that growth hormone may influence the SRIF content of hypothalamus and it seems likely that a feedback mechanism between pituitary GH and hypothalamic SRIF exists.
研究了垂体切除和注射牛生长激素对大鼠下丘脑生长抑素（SRIF）含量的影响。SRIF含量采用其他地方描述的特异性放射免疫分析方法测定。垂体切除4周后，大鼠下丘脑的总SRIF含量及其每毫克湿重的含量均下降，但在垂体切除3周后接受7天牛生长激素注射的大鼠中，其含量显著恢复。此外，在未手术的大鼠中，注射生长激素7天后观察到下丘脑SRIF含量增加。这些结果表明，生长激素可能影响下丘脑的SRIF含量，垂体生长激素和下丘脑SRIF之间似乎存在反馈机制。
