Djurup R
Allergy. 1981 Jul;36(5):289-307. doi: 10.1111/j.1398-9995.1981.tb01581.x.
Since Szentivanyi proposed the idea that asthma and other atopic diseases are due to a beta adrenergic defect there has been much interest in the role of the adrenergic receptors in allergy. The radioactive ligand binding techniques developed within the last few years have greatly increased our knowledge concerning the molecular nature of the adrenoceptors and the events following receptor stimulation. The adrenoceptors have shown to be very dynamic structures. Their number and affinity may be altered due to various physiological and pharmacological stimuli. Their role in the pathogenesis of atopic diseases has not been definitely settled, but there seem to be a true beta adrenergic hyporesponsiveness and alpha hyperresponsiveness in asthma. This article briefly describes the radioligand binding technique and summarizes our present knowledge of the nature of the alpha and beta adrenoceptors and their possible role in atopic diseases.
自从森蒂瓦尼提出哮喘和其他特应性疾病是由于β肾上腺素能缺陷这一观点以来，人们对肾上腺素能受体在过敏中的作用产生了浓厚兴趣。在过去几年中发展起来的放射性配体结合技术极大地增加了我们对肾上腺素能受体的分子性质以及受体刺激后发生的事件的了解。已表明肾上腺素能受体是非常动态的结构。由于各种生理和药理刺激，它们的数量和亲和力可能会改变。它们在特应性疾病发病机制中的作用尚未明确确定，但哮喘中似乎存在真正的β肾上腺素能低反应性和α高反应性。本文简要描述了放射性配体结合技术，并总结了我们目前对α和β肾上腺素能受体的性质及其在特应性疾病中可能作用的认识。
