单次口服氯氮䓬后N-去甲基地西泮的药代动力学：吸烟的影响。

Pharmacokinetics of N-desmethyldiazepam after a single oral dose of clorazepate: the effect of smoking.

作者信息

Norman T R, Fulton A, Burrows G D, Maguire K P

出版信息

Eur J Clin Pharmacol. 1981;21(3):229-33. doi: 10.1007/BF00627925.

PMID:6119204

Abstract

The pharmacokinetics of N-desmethyldiazepam was evaluated after oral administration of clorazepate 20 mg to 12 healthy male volunteers (6 smokers; 6 non-smokers), aged 23-29 years. Plasma levels of desmethyldiazepam were measured by gas liquid chromatography. The half life of elimination (t1/2 beta) was significantly longer in the non-smoking volunteers than in the smokers: 54.7 +17.7 versus 29.8 +9.9 h (p less than 0.05). Peak plasma concentrations (Cmax) were higher in non-smokers than in smokers, 413 +106 micrograms/l and 245 +50 micrograms/l, respectively (p less than 0.05). The sedative effect of clorazepate was less severe in smokers than in non-smokers.

摘要

对12名年龄在23 - 29岁的健康男性志愿者（6名吸烟者；6名不吸烟者）口服20毫克氯氮䓬后，评估了去甲西泮的药代动力学。采用气液色谱法测定血浆中去甲西泮的水平。非吸烟志愿者的消除半衰期（t1/2β）显著长于吸烟者：分别为54.7 + 17.7小时和29.8 + 9.9小时（p < 0.05）。非吸烟者的血浆峰值浓度（Cmax）高于吸烟者，分别为413 + 106微克/升和245 + 50微克/升（p < 0.05）。氯氮䓬对吸烟者的镇静作用比对不吸烟者的作用轻。