吸烟者体内药物代谢增强。
Enhanced drug metabolism in cigarette smokers.
作者信息
Hart P, Farrell G C, Cooksley W G, Powell L W
出版信息
Br Med J. 1976 Jul 17;2(6028):147-9. doi: 10.1136/bmj.2.6028.147.
Abstract
The effect of cigarette smoking on salivary antipyrine disappearance rate, and as an index of hepatic drug metabolism, was studied in 42 healthy subjects. Antipyrine half life was significantly shorter in smokers compared with non-smokers. To determine whether this difference was due solely to tobacco consumption eight subjects were restudied two months after they stopped smoking. The mean antipyrine disappearance rate in this group increased by 23% in contrast to that of a control group, which did not alter. Cigarette smoking contributes to the considerable variation in interindividual rates of drug metabolism.
摘要
在42名健康受试者中研究了吸烟对唾液中安替比林消失率的影响，以此作为肝脏药物代谢的指标。与不吸烟者相比，吸烟者的安替比林半衰期明显更短。为了确定这种差异是否仅由烟草消费引起，对8名受试者在戒烟两个月后进行了重新研究。与未改变的对照组相比，该组安替比林的平均消失率提高了23%。吸烟导致药物代谢个体间速率存在显著差异。
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