B-HT 920对大鼠离体灌注后肢的α2-肾上腺素能受体激动作用。
alpha 2-Adrenoceptor agonistic effect of B-HT 920 in isolated perfused hindquarters of rats.
作者信息
Kobinger W, Pichler L
出版信息
Eur J Pharmacol. 1981 Nov 19;76(1):101-5. doi: 10.1016/0014-2999(81)90016-9.
In isolated perfused hindquarters of rats pretreated with reserpine the alpha 2-adrenoceptor selective agonist B-HT 920 decreased the flow dose-dependently. This effect was strongly antagonized by yohimbine and less by prazosin, and the reverse potency was demonstrated for methoxamine. With increasing concentrations of B-HT 920, a half maximal effect was achieved with 10(-6.64) M. This value is discussed wih respect to the antagonistic potency of B-HT 920 at alpha 1-adrenoceptors with a pA2 of 4.9.
在经利血平预处理的大鼠离体灌注后肢中，α2 -肾上腺素能受体选择性激动剂B-HT 920剂量依赖性地降低血流量。育亨宾能强烈拮抗此效应，哌唑嗪的拮抗作用较弱，而甲氧明则表现出相反的效力。随着B-HT 920浓度增加，10(-6.64) M时达到半数最大效应。结合B-HT 920对α1 -肾上腺素能受体的拮抗效力（pA2为4.9）对该值进行了讨论。
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