Abdel-Halim M N, Yousufzai S Y
Experientia. 1981 Nov 15;37(11):1167-8. doi: 10.1007/BF01989898.
Compared with rats fed a normal diet, the activity of the protein inhibitor of acetyl CoA carboxylase in rat liver doubled after 48 h of fasting. Conversely, acetyl CoA carboxylase activity was diminished by nearly one half. In animals fasted and then subsequently refed a fat free diet, acetyl CoA carboxylase activity was elevated by nearly 9-fold, with a concomitant decrease in the activity of the protein inhibitor by about 9-fold as compared to fasted rats. Hence it appears that the regulatory protein inhibitor for acetyl CoA carboxylase is of physiological significance for fatty acid biosynthesis.
与喂食正常饮食的大鼠相比，禁食48小时后，大鼠肝脏中乙酰辅酶A羧化酶的蛋白抑制剂活性增加了一倍。相反，乙酰辅酶A羧化酶的活性降低了近一半。在禁食后再喂食无脂饮食的动物中，与禁食大鼠相比，乙酰辅酶A羧化酶的活性提高了近9倍，同时蛋白抑制剂的活性降低了约9倍。因此，乙酰辅酶A羧化酶的调节蛋白抑制剂对脂肪酸生物合成具有生理意义。
