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Inhibition of Ca-movement and mechanical movement in rabbit taenia coli by a smooth muscle relaxant (suloctidil).

作者信息

Takayanagi I, Koike K, Yoshida Y, Kaneko M

出版信息

J Pharmacobiodyn. 1981 Oct;4(10):798-802. doi: 10.1248/bpb1978.4.798.

DOI:10.1248/bpb1978.4.798
PMID:6119359
Abstract

A smooth muscle relaxant (suloctidil) relaxed a contractile response of taenia coli to acetylcholine and noncompetitively depressed a dose response curve of Cacl2 Ca-uptake by the microsomal fraction was inhibited by suloctidil. Its noncompetitive antiacetylcholine activity and inhibitory action on Ca-uptake were not influenced by an increase of external Ca-concentration. Ca-release from the Ca-incorporated microsomal fraction was not significantly influenced by suloctidil. These results suggest that suloctidil inhibit Ca-influx noncompetitively, thus inducing smooth muscle relaxation.

摘要

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