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3H-倍他洛尔(β受体阻滞剂)在有色家兔眼组织黑色素颗粒中的掺入。I. 光学显微镜放射自显影术

Incorporation of 3H-befunolol (beta-blocking agent) into melanin granules of ocular tissues in the pigmented rabbits. I. Light microscopic radioautography.

作者信息

Yamabayashi S, Gunarso W, Tsukahara S, Nagata T

出版信息

Histochemistry. 1981 Dec;73(3):371-5. doi: 10.1007/BF00495651.

DOI:10.1007/BF00495651
PMID:6120151
Abstract

3H-befunolol was administered intravenously to pigmented rabbits. Thirty minutes after the administration, the iris, ciliary body and retina were fixed, embedded and processed for light microscopic radioautography. Radioautographical silver grains were observed over the pigment granules of the iris, ciliary body, choroid and retina. From these results it is concluded that 3H-befunolol is incorporated into the pigment granules of these cells. The mechanism of incorporation is discussed.

摘要

将3H-倍他洛尔静脉注射给有色家兔。给药30分钟后,将虹膜、睫状体和视网膜固定、包埋并进行光镜放射自显影处理。在虹膜、睫状体、脉络膜和视网膜的色素颗粒上观察到放射自显影银粒。根据这些结果得出结论,3H-倍他洛尔被摄入这些细胞的色素颗粒中。并对摄入机制进行了讨论。

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A radioautographic study on the incorporation of 14C-bupranolol (beta-blocking agent) into the rabbit eye.
Histochemistry. 1980;68(3):237-44. doi: 10.1007/BF00493253.
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Autoradiographic evidence for binding of 3H-flunitrazepam (Rohypnol) to melanin granules in the cat eye.
Experientia. 1980 Jul 15;36(7):863-5. doi: 10.1007/BF01978617.
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