醋酸苯汞（PhMA）中毒大鼠丘脑核的组织酶学变化。

Histoenzymatic changes in the thalamic nuclei of rats intoxicated by phenyl-mercury acetate (PhMA).

作者信息

Wigowska-Sowińska J

出版信息

J Hirnforsch. 1981;22(5):563-71.

PMID:6120192

Abstract

The effect of ingestion of phenylmercury acetate (PhMA), a fungicide of wide agricultural application, on the histoenzymatic pattern of the thalamic nuclei was investigated. It has been shown that in rats administered via a gastric tube with 8 mg of PhMA for 10 consecutive days, a considerable drop of AChE, BuTJ, acP and ATPase activities in many thalamic nuclei was found. Beside the inhibition of many enzymes, TPPase and NsE activities were increased. The histoenzymatic response of the individual thalamic nuclei to PhMA intoxication was highly differentiated. A detailed list of results obtained are presented in tables I and II.

摘要

研究了广泛应用于农业的杀菌剂醋酸苯汞（PhMA）的摄入对丘脑核组织酶模式的影响。结果表明，连续10天经胃管给大鼠施用8毫克PhMA后，发现许多丘脑核中的乙酰胆碱酯酶（AChE）、丁酰硫代胆碱酯酶（BuTJ）、酸性磷酸酶（acP）和三磷酸腺苷酶（ATPase）活性显著下降。除了许多酶受到抑制外，焦磷酸酶（TPPase）和非特异性酯酶（NsE）活性增加。各个丘脑核对PhMA中毒的组织酶反应高度分化。所得结果的详细列表见表I和表II。