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J Neurosci Methods. 1980 Jun;2(3):219-38. doi: 10.1016/0165-0270(80)90012-6.
The social interaction test in rats provides a method for detecting anxiolytic activity that does not use food or water deprivation, or electric shock, and therefore obviates difficulties of interpretation that might arise from drug-induced changes in motivation. Since social interaction is measured under more than one test condition any overall increase or decrease in social behaviour can be detected independently from the drug x test condition interaction that characterizes an anxiolytic drug. The Geller-Seifter conflict test was designed with two schedules of reinforcement for the same reasons. Any candidate test for anxiolytic action that examines drug effects under only one experimental condition is open to misinterpretation and may also prove unreliable if the critical experimental factors ( e.g. the level of food deprivation or the shock intensity) are changed. The testing procedure in the social interaction test is relatively time consuming in terms of observer-hours, but no lengthy pretraining of the animals is required. There is no way of fully automating the scoring and therefore it is important that the observers do not know the experimental group of the rats that they are scoring, and that tape recordings are made so that the scores can be checked. It has not so far been fruitful to analyze drug effects on every individual social behaviour, but this method does allow changes in individual behaviours to be detected. By entering the data directly into a computer we are now able to store the frequency and duration of each behaviour as well as the sequence of behaviours. It will then be possible to determine whether a detailed analysis of drug effects on the patterning of social behaviours will prove a useful addition to the social interaction test
大鼠的社会互动测试提供了一种检测抗焦虑活性的方法，该方法不使用食物或水剥夺，也不使用电击，因此避免了因药物引起的动机变化可能产生的解释困难。由于社会互动是在多种测试条件下进行测量的，所以任何社会行为的总体增加或减少都可以独立于表征抗焦虑药物的药物x测试条件相互作用来检测。出于同样的原因，盖勒-塞夫特冲突测试设计了两种强化程序。任何仅在一种实验条件下检查药物作用的抗焦虑作用候选测试都容易产生误解，而且如果关键实验因素（如食物剥夺水平或电击强度）发生变化，也可能被证明不可靠。就观察时间而言，社会互动测试中的测试程序相对耗时，但不需要对动物进行长时间的预训练。没有办法完全自动化评分，因此重要的是观察者不知道他们正在评分的大鼠的实验组，并且要进行录音以便可以检查分数。到目前为止，分析药物对每一种个体社会行为的影响并没有取得成果，但这种方法确实能够检测到个体行为的变化。通过将数据直接输入计算机，我们现在能够存储每种行为的频率和持续时间以及行为序列。然后就有可能确定对社会行为模式的药物作用进行详细分析是否会成为社会互动测试的有益补充。
