King M G, Geffard M R, Chavreau J, Gaffori O, Le Moal M, Muyard J P
Eur J Pharmacol. 1981 Dec 3;76(2-3):271-4. doi: 10.1016/0014-2999(81)90512-4.
In this experiment we investigated in rats the effects of chronic injections (13 X 1.0 microgram and 13 X 2 micrograms i.m.) and one acute injection (0.3 microgram s.c.) of des-Tyr-gamma-endorphin (DT gamma E) on the pineal content of melatonin and arginine vasopressin (AVP). Compared with control levels all three regimens of DT gamma E significantly elevated pineal melatonin. The greatest increase was obtained with the 0.3 microgram acute dose while the smallest increase was obtained with the 2 micrograms chronic dose. In contrast to the effect on melatonin, pooled levels of pineal AVP were lower in DT gamma E treated rats than in control rats. The greatest reduction was obtained with the 2 microgram chronic dose and the smallest reduction was obtained with the 1 microgram chronic dose.
在本实验中，我们研究了对大鼠进行慢性注射（13次，每次1.0微克和13次，每次2微克，肌肉注射）以及单次急性注射（0.3微克，皮下注射）去酪氨酸γ-内啡肽（DTγE）对松果体中褪黑素和精氨酸加压素（AVP）含量的影响。与对照水平相比，所有三种DTγE给药方案均显著提高了松果体褪黑素水平。0.3微克急性剂量导致的增加最大，而2微克慢性剂量导致的增加最小。与对褪黑素的影响相反，DTγE处理的大鼠松果体AVP的合并水平低于对照大鼠。2微克慢性剂量导致的降低最大，1微克慢性剂量导致的降低最小。
