Tiengo A, Bessioud M, Valverde I, Tabbi-Anneni A, Delprato S, Alexandre J, Assan R
Diabetologia. 1982 Jan;22(1):25-32. doi: 10.1007/BF00253865.
Plasma immunoreactive glucagon, C-peptide and substrates (glucose, lactate, and alanine) were measured in 21 pancreatectomized patients and 28 patients with chronic calcifying pancreatitis during arginine infusion. Results were compared with those obtained in control and in insulin-dependent diabetic subjects, and in pancreatectomized subjects receiving a combined infusion of glucagon and arginine or somatostatin and arginine. Plasma immunoreactive glucagon in the pancreatectomized patients was 230 +/- 26 pg/ml (control subjects 100 +/- 13 pg/ml, p less than 0.001), but was unchanged following arginine or somatostatin. Following ethanol extraction of plasma it became undetectable. Similar results were obtained in patients with chronic pancreatitis. In contrast to the insulin-dependent diabetic subjects, no changes in blood glucose, lactate, and alanine concentrations were found during arginine infusion in the pancreatectomized or pancreatitis patients. Addition of glucagon restored the metabolic response to arginine in the pancreatectomized patients. Our results confirm previous smaller studies that in pancreatectomized patients, A cell function is absent or insignificant.
在21例胰腺切除患者和28例慢性钙化性胰腺炎患者静脉输注精氨酸期间，检测了血浆免疫反应性胰高血糖素、C肽和底物（葡萄糖、乳酸和丙氨酸）。将结果与在对照组、胰岛素依赖型糖尿病患者以及接受胰高血糖素和精氨酸联合输注或生长抑素和精氨酸联合输注的胰腺切除患者中获得的结果进行比较。胰腺切除患者的血浆免疫反应性胰高血糖素为230±26 pg/ml（对照组为100±13 pg/ml，p<0.001），但在输注精氨酸或生长抑素后无变化。血浆经乙醇提取后无法检测到。慢性胰腺炎患者也得到了类似结果。与胰岛素依赖型糖尿病患者不同，胰腺切除或胰腺炎患者在输注精氨酸期间血糖、乳酸和丙氨酸浓度无变化。添加胰高血糖素可恢复胰腺切除患者对精氨酸的代谢反应。我们的结果证实了先前规模较小的研究，即在胰腺切除患者中，A细胞功能缺失或不显著。
