Harvengt C, Desager J P
Int J Clin Pharmacol Ther Toxicol. 1982 Feb;20(2):57-61.
The pharmacokinetics of a single dose (75 mg) of dl-moprolol and l-moprolol, a new beta -blocking agent, were appraised over 3 days in two groups of ten volunteers. The peak plasma level (GLC method) (598 +/- 99 ng/ml), the area under the curve (3.054 +/- 578 ng.ml/h), and 24-h urinary excretion (34.83 +/- 6.33 mg) after 1-moprolol intake were more elevated than after dl-moprolol intake. However, the plasma elimination half-life was not statistically different, 2.3 +/- 0.26 h after 1-moprolol versus 2.11 +/- 0.3 h after dl-moprolol. The double product (systolic blood pressure x heart rate) was significantly decreased only in volunteers after receiving 1-moprolol but not after dl-moprolol. The mean pharmacodynamic half-life estimated from exercise heart rate after dl-moprolol was 11.6 h.
在两组各10名志愿者中，对单剂量（75毫克）的消旋美多洛尔和新型β受体阻滞剂左旋美多洛尔的药代动力学进行了为期3天的评估。服用左旋美多洛尔后的血浆峰值水平（气相色谱法）（598±99纳克/毫升）、曲线下面积（3.054±578纳克·毫升/小时）和24小时尿排泄量（34.83±6.33毫克）均高于服用消旋美多洛尔后。然而，血浆消除半衰期无统计学差异，左旋美多洛尔后为2.3±0.26小时，消旋美多洛尔后为2.11±0.3小时。仅在服用左旋美多洛尔的志愿者中，双乘积（收缩压×心率）显著降低，而服用消旋美多洛尔后未降低。根据运动心率估算，消旋美多洛尔的平均药效学半衰期为11.6小时。
