Nana A, Cardan E, Cucuianu M
Acta Anaesthesiol Belg. 1977;28(3):183-7.
Pseudocholinesterase activity was investigated in three groups of unselected patients. A slight rise of the enzyme was found during surgery under local anesthesia with lidocaine. In general anesthesia with thiopentone and halothane, the pseudocholinesterase activity diminished. The inhibition was more pronounced when pancuronium had been injected. From these data one may conclude that pancuronium must be carefully given in patients with low level of pseudocholinesterase when other drugs inhibiting the enzyme activity, like succinylcholine, procaine and propanidid, are used.
对三组未经挑选的患者进行了假性胆碱酯酶活性研究。在使用利多卡因进行局部麻醉手术期间，发现该酶有轻微升高。在使用硫喷妥钠和氟烷进行全身麻醉时，假性胆碱酯酶活性降低。注射泮库溴铵后，抑制作用更明显。从这些数据可以得出结论，当使用琥珀酰胆碱、普鲁卡因和丙泮尼地等其他抑制酶活性的药物时，假性胆碱酯酶水平低的患者必须谨慎使用泮库溴铵。
