乙酰胆碱作为神经递质参与外侧前庭核的电生理证据。

Electrophysiologic evidence for involvement of acetylcholine as a neurotransmitter in the lateral vestibular nucleus.

作者信息

Ito J, Matsuoka I, Sasa M, Fujimoto S, Takaori S

出版信息

Otolaryngol Head Neck Surg. 1981 Nov-Dec;89(6):1025-9. doi: 10.1177/019459988108900629.

DOI:10.1177/019459988108900629

Abstract

Monosynaptic spike generation of lateral vestibular nucleus (LVN) neurons with vestibular nerve stimulation in cats was inhibited by microiontophoretic atropine and gamma-aminobutyric acid (GABA). Spontaneous firing of the LVN monosynaptic neuron was increased by iontophoretic acetylcholine and glutamate. Atropine inhibited acetylcholine-induced firing without affecting glutamate-induced firing, while GABA blocked spike generation produced by acetylcholine and glutamate. Acetylcholine probably plays a role in transmission from the vestibular nerve to the LVN monosynaptic neurons.

摘要

猫的前庭神经刺激诱发外侧前庭核（LVN）神经元单突触放电，可被微量离子电泳阿托品和γ-氨基丁酸（GABA）抑制。离子电泳乙酰胆碱和谷氨酸可增加LVN单突触神经元的自发放电。阿托品抑制乙酰胆碱诱发的放电，但不影响谷氨酸诱发的放电，而GABA阻断乙酰胆碱和谷氨酸产生的突触放电。乙酰胆碱可能在前庭神经至LVN单突触神经元的传递中起作用。