Toth E, Lajtha A
Neurochem Res. 1981 Dec;6(12):1309-17. doi: 10.1007/BF00964352.
Taurine, aspartic acid, glutamic acid, glycine, and GABA were administered either intragastrically or in liquid diets to mice and rats. This resulted in a great increase in the plasma concentration of the administered amino acid, with plasma levels remaining elevated for several days. The prolonged increase in plasma levels resulted in significant increases in brain levels. Under these experimental conditions, taurine, aspartic acid, and glutamic acid were increased 30-60%; glycine and GABA 100%. During these experiments, plasma levels of taurine, aspartate, and glutamate were below brain levels; those of glycine and GABA were above. The findings show that even slowly penetrating amino acid levels can be increased in brain after parenteral administration of large doses.
将牛磺酸、天冬氨酸、谷氨酸、甘氨酸和γ-氨基丁酸经胃内或添加到液体饲料中给予小鼠和大鼠。这导致所给予氨基酸的血浆浓度大幅增加，血浆水平会持续升高数天。血浆水平的持续升高导致脑内水平显著增加。在这些实验条件下，牛磺酸、天冬氨酸和谷氨酸增加了30% - 60%；甘氨酸和γ-氨基丁酸增加了100%。在这些实验过程中，牛磺酸、天冬氨酸和谷氨酸的血浆水平低于脑内水平；甘氨酸和γ-氨基丁酸的血浆水平则高于脑内水平。这些研究结果表明，经肠胃外给予大剂量氨基酸后，即使是穿透缓慢的氨基酸在脑内的水平也会升高。
