Bonilla E, Prasad A L, Arrieta A
Instituto de Investigaciones Clinicas, Universidad del Zulia, Maracaibo, Venezuela.
Life Sci. 1988;42(11):1153-8. doi: 10.1016/0024-3205(88)90610-8.
We studied the levels of free amino acids in putamen and Brodmann's area 10 of 12 patients who died with Huntington's disease and 13 non-neurologic controls. GABA, glutamate and alpha-amino-n-butyric acid concentrations were found to be reduced in putamen of Huntington's disease patients. In Brodmann's area 10 the levels of glutamate, histidine and lysine were decreased, but the content of aspartate, GABA, glycine, serine and taurine was increased in the same group of patients.
我们研究了12例死于亨廷顿舞蹈症患者以及13名非神经疾病对照者的壳核和布罗德曼第10区中的游离氨基酸水平。发现亨廷顿舞蹈症患者壳核中的γ-氨基丁酸、谷氨酸和α-氨基-n-丁酸浓度降低。在布罗德曼第10区，同一组患者的谷氨酸、组氨酸和赖氨酸水平降低，但天冬氨酸、γ-氨基丁酸、甘氨酸、丝氨酸和牛磺酸含量增加。
