Gleadhill I C, Smith T A, Yium J J
South Med J. 1982 Apr;75(4):426-8. doi: 10.1097/00007611-198204000-00012.
Although there is a definite association between hyponatremia and schizophrenia, the true incidence and etiology have not been established. This report is a retrospective study of all admissions to the Baroness Erlanger Hospital over a three and one-half year period. There was a 5.8% incidence of hyponatremia in patients with schizophrenia as compared with a 0.36% incidence for all admission (P less than .01). Schizophrenic patients at risk for developing hyponatremia drank water excessively(P less than .01) and were most likely to be taking thioxanthene (P = .05(4)) antipsychotic and anticholinergic medications (P Less than .01). Most schizophrenic patients admitted with hyponatremia had dangerously low serum sodium levels (less than or equal to 120 mEq) and showed severe neurologic dysfunction. This retrospective study compares the clinical features of schizophrenic patients who develop hyponatremia and those who do not. The possible role of antidiuretic hormone is discussed
尽管低钠血症与精神分裂症之间存在明确关联，但真正的发病率和病因尚未明确。本报告是对埃兰格男爵夫人医院三年半期间所有入院病例的回顾性研究。精神分裂症患者低钠血症的发病率为5.8%，而所有入院患者的发病率为0.36%（P<0.01）。有发生低钠血症风险的精神分裂症患者饮水过量（P<0.01），且最有可能正在服用硫杂蒽类（P=0.05(4)）抗精神病药物和抗胆碱能药物（P<0.01）。大多数因低钠血症入院的精神分裂症患者血清钠水平极低（≤120 mEq），并表现出严重的神经功能障碍。这项回顾性研究比较了发生低钠血症和未发生低钠血症的精神分裂症患者的临床特征。文中还讨论了抗利尿激素可能发挥的作用。
