Yano T, Yamamoto N, Fujimori K, Inamori S, Hayashi H, Mizumoto R
Am J Gastroenterol. 1982 Jun;77(6):387-91.
A patient with glucagonoma syndrome and hypoglycemic attack is presented. Total pancreatectomy was performed with splenectomy and excision of the metastatic nodule in the liver. Diagnosis of glucagon-secreting A cell carcinoma of the pancreas was confirmed by hormone assays and morphological studies with light and electron microscopy. Glucagon, insulin, and somatostatin were demonstrated immunohistochemically in the tumor tissue. Multihormonal features of the endocrine pancreatic tumors are discussed.
本文报告一例患有胰高血糖素瘤综合征并发生低血糖发作的患者。行全胰切除术，同时切除脾脏及肝脏转移结节。通过激素测定以及光镜和电镜的形态学研究，确诊为胰腺分泌胰高血糖素的A细胞癌。在肿瘤组织中通过免疫组织化学法检测到了胰高血糖素、胰岛素和生长抑素。文中讨论了胰腺内分泌肿瘤的多激素特征。
