Booij L H, Crul J F, van der Pol F
Anasth Intensivther Notfallmed. 1982 Apr;17(2):78-80. doi: 10.1055/s-2007-1003851.
The pharmacodynamics of neostigmine 20 micrograms kg-1 reversing a constant neuromuscular blockade from continuous infusion of Org NC 45 was studied in 17 cats. Six cats received only intravenous thiopental anaesthesia, another five received a 1 MAC (0.73%) inhalational concentration of halothane, and the remaining six cats received 1 MAC (1.68%) enflurane. In the enflurane group statistically significantly less Org NC 45 was needed to maintain the blockade (p less than 0.05). There was no difference in the degree of reversal or in the time course of the neostigmine activity between the 3 groups (p greater than 0.05). Only the duration of action of neostigmine was prolonged under halothane anaesthesia.
在17只猫身上研究了20微克/千克新斯的明逆转持续输注Org NC 45所致恒定神经肌肉阻滞的药效学。6只猫仅接受静脉硫喷妥钠麻醉，另外5只接受1个最低肺泡有效浓度（0.73%）的氟烷吸入浓度，其余6只猫接受1个最低肺泡有效浓度（1.68%）的恩氟烷。在恩氟烷组，维持阻滞所需的Org NC 45在统计学上显著较少（p<0.05）。3组之间在新斯的明的逆转程度或作用时间过程方面无差异（p>0.05）。仅在氟烷麻醉下新斯的明的作用持续时间延长。
