Baker J F, Chalecki B W, Benziger D P, O'Melia P E, Clemans S D, Edelson J
Drug Metab Dispos. 1982 Mar-Apr;10(2):168-72.
The biotransformation of 14C-amrinone was studied in rats, dogs, and monkeys by automated gradient high-performance liquid chromatography. The major pathways of metabolism elucidated are: A) glucuronidation at the primary amino nitrogen atom and/or the enolized oxygen atom of the pyridone ring; B) addition of glutathione at the pyridone 2-position and ultimate hydrolysis of this compound to the 2-S-cysteinyl metabolite; C) formation of the primary amino N-acetyl derivative and subsequent oxidation of this to the corresponding N-glycolate. In each species studied, urine was the primary route of elimination and unchanged amrinone was the major urinary excretion product, the other known pathways being: rat, A and C; dog, A and B; monkey, A.
通过自动梯度高效液相色谱法研究了大鼠、狗和猴子体内14C-氨力农的生物转化。所阐明的主要代谢途径如下：A）在吡啶酮环的伯氨基氮原子和/或烯醇化氧原子处进行葡萄糖醛酸化；B）在吡啶酮2位添加谷胱甘肽，并最终将该化合物水解为2-S-半胱氨酰代谢物；C）形成伯氨基N-乙酰衍生物，并随后将其氧化为相应的N-乙醇酸酯。在所研究的每个物种中，尿液是主要的排泄途径，未变化的氨力农是主要的尿排泄产物，其他已知途径为：大鼠，途径A和C；狗，途径A和B；猴子，途径A。
