谷氨酸对大鼠纹状体突触体摄取45Ca的刺激作用。

Glutamate stimulation of 45Ca uptake by rat striatal synaptosomes.

作者信息

Retz K C, Young A C, Coyle J T

出版信息

Eur J Pharmacol. 1982 Apr 23;79(3-4):319-22. doi: 10.1016/0014-2999(82)90640-9.

Abstract

The effects of acidic excitatory amino acids and 60 mM K+ on 45Ca uptake by synaptosomes prepared from rat striatum were examined. Both glutamic acid and 60 mM K+ significantly stimulated the uptake of 45Ca and these effects were antagonized by 30 mM Mg2+ and 0.5 mM La3+ but not by 5 microM tetrodotoxin. Neither kainic acid nor N-methyl-D,L-aspartic acid significantly affected the uptake of 45Ca. The results suggest that glutamate may activate a presynaptic receptor that is directly linked to calcium channels.

摘要

研究了酸性兴奋性氨基酸和60 mM K⁺对从大鼠纹状体制备的突触体摄取⁴⁵Ca的影响。谷氨酸和60 mM K⁺均显著刺激了⁴⁵Ca的摄取，这些作用被30 mM Mg²⁺和0.5 mM La³⁺拮抗，但不被5 μM河豚毒素拮抗。 kainic酸和N-甲基-D，L-天冬氨酸均未显著影响⁴⁵Ca的摄取。结果表明，谷氨酸可能激活了与钙通道直接相连的突触前受体。