Nevskiĭ M P, Zaika V G, Makliakov Iu S
Farmakol Toksikol. 1982 May-Jun;45(3):50-2.
Altogether 32 patients with different depressive states received noveril. The drug was administered in the doses of 180, 160, 240 and 320 mg in the first half of the day. Complete egress from the depressive state and considerable improvement were observed in 46% of the patients, slight improvement in 38% and no visible improvement was recorded in 16% of the patients. The data obtained enable the assessment of noveril as a primarily activation antidepressant with a rapid manifestation of therapeutic effect. The drug is indicated in classical depressions, adynamic subdepressions, obsessional depressions and cyclothymic subdepressions. The drugs are used in the doses about 160-240 mg. It was established that noveril should be used with caution in patients with arterial pressure fluctuations. In senesthopathic and hypochondriac conditions, noveril is either ineffective or leads to the patients' state deterioration.
共有32名不同抑郁状态的患者服用了诺韦里尔。该药物于上午分剂量180、160、240和320毫克服用。46%的患者完全摆脱抑郁状态且有显著改善，38%的患者有轻微改善，16%的患者未见明显改善。所获数据表明诺韦里尔可作为一种主要具有激活作用的抗抑郁药，治疗效果显现迅速。该药适用于典型抑郁症、无力性亚抑郁症、强迫性抑郁症和环性心境障碍性亚抑郁症。药物用量约为160 - 240毫克。已确定动脉压波动的患者应谨慎使用诺韦里尔。在老年病和疑病症状态下，诺韦里尔要么无效，要么会导致患者病情恶化。
